MULTICENTER, DOUBLE-BLIND, PLACEBO-CONTROLLED TRIAL OF SEVIPROTIMUT-L POLYVALENT MELANOMA VACCINE IN PATIENTS WITH POST-RESECTION MELANOMA AT HIGH RISK OF RECURRENCE

Background Most patients with advanced melanomas relapse after checkpoint blockade therapy.Thus, immunotherapies are needed that can be applied safely early, in the adjuvant setting.Seviprotimut-L is a vaccine containing human melanoma antigens, plus alum.To assess the efficacy of seviprotimut-L, the Melanoma Antigen Vaccine Immunotherapy Study (MA

Abstract Background Treatment of superficial venous reflux has been shown to improve ulcer healing time and reduce the risk of ulcer recurrence.Terminal ablation of the reflux source (TIRS) is an alternative to formal endovenous ablation or surgery which can be performed by injecting sclerosant foam into the peri-ulcer plexus of the veins.TIRS has

ABSTRACT: Introduction: Recent studies have reported that the quarantine imposed in several countries around the world due to Covid-19 affected the sexual function and relationship quality.On the March 23, 2020 the Greek government imposed a national quarantine to contain the spread of the pandemic.The impact of such conditions on Lid Switch Bracke

The current debate about the diagnostic significance of delusion revolves around two positions.The neurocognitive position conceives delusion as a non-specific, though polymorphic, symptom.The psychopathological position views features of delusion such as content and structure as having meaningful connections with diagnostic entities.This study aim

Regular physical activity is an effective strategy to prevent and ameliorate aging-associated diseases.In particular, training increases muscle Flu Support performance and improves whole-body metabolism.Since exercise affects the whole organism, it has countless health benefits.The systemic effects of exercise can, in part, be explained by communic